HYPOESTOXIDES, DERIVATIVES AND AGONISTS THEREOF FOR USE AS INHIBITORS OF ANGIONGENESIS

摘要

A method for inhibiting angiogenesis in a mammal, the method comprising administering to a mammal an effective amount of a compound having the formula (I) and pharmaceutically acceptable salts thereof, wherein R is selected from the group consisting of (a) H (b) PO3 (c) PO3M, wherein M is selected from the group consisting of an alkali metal salt and an alkaline earth metal salt, (d) PO2M2, wherein each M is independently selected form the group consisting of alkali metal salts and alkaline earth metal salts (e) alkyl of 1 to 12 carbon atoms, which may be either substituted or unsubstituted, straight-chain or branched, having 0 to 6 double bonds (f) (CH2)n morpholine, wherein n = 1 to 4 (g) morpholinomethylphenyl (h) orthoaminophenyl (i) orthohydroxyphenyl (j) (CH2)mCOOR2, wherein m = 1 to 4, R2 is selected from the group consisting of H, an alkali metal salt, an alkaline earth metal salt, NH4<+>, and N<+>(R3)4, wherein each R3 is independently selected from the group consisting of H and alkyl of 1 to 4 carbon atoms; (k) COR1, wherein R1 is selected from the group consisting of H, (CH2)pCH3, wherein p = 0 to 6, (CH2)mCOOR2, wherein m and R2 are previously defined, and (CH2)rSO3, wherein r = 1 to 4.