HUMANIZATION OF AN ANTI-CARCINOEMBRYONIC ANTIGEN ANTI-IDIOTYPE ANTIBODY AND USE AS A TUMOR VACCINE AND FOR TARGETING APPLICATIONS

摘要

A humanized form of an antiidiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of antiCEA antibodies are maximized by using the humanized antiidiotype as a clearing agent for antiCEA antibodies or antibody fragments. The humanized antiidiotype also can be used as an immunogenic vaccine.