发明名称 |
Redirection of cellular immunity by protein tyrosine kinase chimeras |
摘要 |
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
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申请公布号 |
US2003053994(A1) |
申请公布日期 |
2003.03.20 |
申请号 |
US20020151193 |
申请日期 |
2002.05.20 |
申请人 |
SEED BRIAN;ROMEO CHARLES;KOLANUS WALDEMAR |
发明人 |
SEED BRIAN;ROMEO CHARLES;KOLANUS WALDEMAR |
分类号 |
A61K35/14;A61K38/00;C07K14/705;C07K14/725;C07K14/73;C07K14/735;C07K19/00;C12N9/12;C12P21/04;(IPC1-7):A61K48/00 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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