Transfection efficiency can be enhanced when a complex comprising a nucleic acid, an antibody that specifically binds the nucleic acid and a cationic macromolecule is introduced into mammalian cells. Delivery of nucleic acid into these cells enable transfection at levels comparable to conventional viral delivery.
申请公布号
WO02094983(A3)
申请公布日期
2003.03.20
申请号
WO2002US11886
申请日期
2002.05.13
申请人
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;LEVY, ROBERT, J.;SONG, CUNXIAN