| 摘要 |
A process is described in which superparamagnetic particles are first conjugated or adsorbed to a group of identical biomolecules,such as a group of antibodies, and the conjugates or adsorbates are then reacted with a group of biological binding partner molecules to form a tightly bound, three-dimensional mass of interlinked biomolecules and bound superparamagnetic particles. The mass is exposed to a magnetic field for the shortest period need to induce magnetization of the superparamagnetic particles and the field is then inmediately removed. The superparamagnetic particles in the mass exhibit in concert a measurable nonpermanent aggregative magnetization for a period of at least twenty minutes which can be used to quantitate the amount of biological binding partner present by comparison with preestablished standards or to confirm the presence of a biological binding partner in a test sample. |
