发明名称 |
PREPARATION PROCESS FOR ATORVASTATIN AND INTERMEDIATES |
摘要 |
The invention relates to a novel process for the preparation of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide and to novel intermediates and process steps therefor. In that process inter alia the intermediate 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide is obtained by nucleophilic substitution from a compound of formula (I), wherein X is a nucleofugal leaving group, with a ketoamide of formula (II) in the presence of a base. |
申请公布号 |
WO03004457(A3) |
申请公布日期 |
2003.03.20 |
申请号 |
WO2002EP07014 |
申请日期 |
2002.06.25 |
申请人 |
CIBA SPECIALTY CHEMICALS HOLDING INC.;SCHOENING, KAI-UWE;HARTWIG, JEMIMA |
发明人 |
SCHOENING, KAI-UWE;HARTWIG, JEMIMA |
分类号 |
C07C231/12;C07C235/78;C07D207/34;C07D405/06 |
主分类号 |
C07C231/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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