METHOD OF SCREENING DRUG AND METHOD OF JUDGING SIGNIFICANCE OF MUTATION IN GENE ENCODING TRANSCRIPTIONAL REGULATORY FACTOR

摘要

A method whereby a compound which is expected as showing a drug effect via the inhibition or regulation of a transcriptional regulatory factor can be screened without using any animals or cells in the test. By this drug screening method, a substance capable of binding to the minor groove of DNA is screened. This method is useful as a primary screening method for immunomodulators, antiviral agents, antiinflammatory agents, remedies for arteriosclerosis, anticancer agents, remedies for hypertension, remedies for diabetics, remedies for failure in infection protective mechanism, etc.