TWO-STEP IMMUNIZATION PROCEDURE AGAINST THE PYRAMYXOVIRIDAE FAMILY OF VIRUSES USING ATTENUATED VIRAL STRAINS AND SUBUNIT PROTEIN PREPARATION
摘要
<p>An immunization strategy to provide protection against disease caused by infection with paramyxoviridae viruses, specifically respiratory syncytial virus (RSV) and parainfluenza virus (PIV), is described. A primary administration of a live attenuated strain of RSV or PIV first is made to the host followed by a booster administration of at least one purified RSV or PIV protein or immunogenic fragment thereof, which may be adjuvanted with alum. This immunization strategy provides a safe and effective means of controlling disease caused by RSV and PIV infections. The strategy leads to a stronger protective immune response than other strategies and to the induction of a more balanced Th-1/Th-2 type response than previously attained.</p>
申请公布号
EP0936921(B1)
申请公布日期
2003.03.19
申请号
EP19970930276
申请日期
1997.07.11
申请人
AVENTIS PASTEUR LIMITED;THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人
KLEIN, MICHEL, H.;CATES, GEORGE, A.;EWASYSHYN, MARY, E.;HERLOCHER, M., LOUISE;MAASSAB, H., F.