| 摘要 |
<p>PCT No. PCT/NL95/00325 Sec. 371 Date May 28, 1997 Sec. 102(e) Date May 28, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09812 PCT Pub. Date Apr. 4, 1996Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.</p> |
