发明名称 |
PACLITAXEL OILY COMPOSITION FOR CHEMOEMBOLIZATION, PREPARATION THEREOF AND PRODUCTION THEREOF |
摘要 |
PURPOSE: A process of preparing a paclitaxel oily composition for chemoembolization by adding paclitaxel to an oily contrast medium and then agitating is provided. The composition is easy to manufacture and sterilize and more physiochemically stable than conventional adriamycin/lipiodol preparation. CONSTITUTION: The paclitaxel oily composition is prepared by mixing 0.0001 to 10mg paclitaxel with 1ml oily contrast medium under sterilization conditions, agitating at room temperature and then sterilized by gamma ray. The oily contrast medium is iodized oil having an iodine content of 30 to 50% selected from iodized poppy seed oil, ethiodol and iodized soybean oil. The composition optionally contains 0.1 to 1ml animal oil such as squalane, vegetable oil such as soybean oil or a mixture thereof, based on 1ml oily contrast medium.
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申请公布号 |
KR20030023369(A) |
申请公布日期 |
2003.03.19 |
申请号 |
KR20010056536 |
申请日期 |
2001.09.13 |
申请人 |
DAE HWA PHARMA. CO., LTD.;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
JUNG, HYE SEON;JUNG, JIN UK;JUNG, SEO YEONG;KIM, YEONG MAN;KWON, IK CHAN;LEE, IN HYEON;PARK, JAE HYEONG |
分类号 |
A61K31/335;A61K9/00;A61K31/337;A61K47/44;A61K49/04;(IPC1-7):A61K31/335 |
主分类号 |
A61K31/335 |
代理机构 |
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