发明名称 |
BENZENE RING-FUSED 5-MEMBERED HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING THE SAME AND USE THEREOF |
摘要 |
<p>PROBLEM TO BE SOLVED: To provide a benzene ring-fused 5-membered heterocyclic compound having medicinal action such as neurotrophic factor action, neurotrophic factor activity-enhancing action andβ-amyloid cytotoxicity-suppressing action. SOLUTION: This compound is represented by general formula (I) [wherein R<1> and R<2> are each independently hydrogen; a hydrocarbon group; or a heterocyclic group; or R<1> and R<2> may form a 3- to 8-membered homo- or hetero-cycle together with the adjacent carbon atom; R<3> is a cyclic group; hydroxyl or optionally oxo-modified mercapto or amino group; R<4> is hydrogen atom, a hydrocarbon group, hydroxyl or optionally oxo-modified mercapto or amino; or R<2> and R<4> may be united to form a double bond; X is a direct bond or a linear hydrocarbon group; W is oxygen or sulfur; the ring B is a 5 to 8-membered nitrogenous heterocycle; the ring C is a benzene ring; the double line composed of the dotted line and the solid line represents a single or double bond] or a salt or a prodrug thereof. The compound or the salt or the prodrug thereof has excellent neurodegeneration inhibiting activity and migration property toward the brain and has low toxicity and is useful as a preventive and therapeutic agent for neurodegenerative diseases.</p> |
申请公布号 |
JP2003081959(A) |
申请公布日期 |
2003.03.19 |
申请号 |
JP20020195424 |
申请日期 |
2002.07.04 |
申请人 |
TAKEDA CHEM IND LTD |
发明人 |
OOKAWA SHIGENORI;MIYAMOTO MASAOMI;OKURA MASAHIRO;TSUKAMOTO TETSUYA |
分类号 |
C07D307/79;A61K31/4525;A61K31/4535;A61K31/496;A61K31/5377;A61K31/55;A61P1/16;A61P1/18;A61P13/12;A61P19/10;A61P21/00;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D307/80;C07D307/81;C07D307/82;C07D307/84;C07D405/04;C07D405/12;C07D405/14;C07D407/04;C07D409/04;C07D409/14;(IPC1-7):C07D307/79;A61K31/452;A61K31/453;A61K31/537 |
主分类号 |
C07D307/79 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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