发明名称 |
AGONIST ANTI-TRK-C MONOCLONAL ANTIBODIES |
摘要 |
The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy. |
申请公布号 |
EP1292680(A2) |
申请公布日期 |
2003.03.19 |
申请号 |
EP20010950429 |
申请日期 |
2001.06.22 |
申请人 |
GENENTECH, INC. |
发明人 |
DEVAUX, BRIGITTE;HONGO, JO-ANNE, S.;PRESTA, LEONARD, G.;SHELTON, DAVID, L. |
分类号 |
C12N15/09;A61K39/395;A61K48/00;A61P9/00;A61P25/00;A61P25/02;A61P25/28;C07K16/28;C07K16/32;C12N5/10;C12N15/02;C12N15/13;C12P21/08;(IPC1-7):C12N15/13;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|