发明名称 |
C peptide for improved preparation of insulin and insulin analogs |
摘要 |
The invention relates to a precursor of human insulin or of an insulin analog of the formula I:whereinFus is an optionally present fusion portion;B(1-30) is a B chain of human insulin,Y is an amino acid chain which terminates with a basic amino acid at the C terminus;n is from 2 to 50 and indicates the length of the amino acid chain Y; andA(1-21) is an A chain of human insulin,and the A chain and/or the B chain can be modified by amino acid substitution, deletions and/or additions. The present invention also provides DNA coding for the above precursors, preparation and use of the instant precursors and DNA, and a process for preparing human insulin or an insulin analog.
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申请公布号 |
US6534288(B1) |
申请公布日期 |
2003.03.18 |
申请号 |
US20000676787 |
申请日期 |
2000.10.02 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
HABERMANN PAUL;ERTL JOHANN;MEIWES JOHANNES;SEIPKE GERHARD |
分类号 |
C12N15/09;C07K14/62;C07K19/00;C12N1/21;C12N15/17;C12P21/02;(IPC1-7):C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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