| 发明名称 |
Therapeutic and diagnostic uses of protein tyrosine phosphatase TC-PTP |
| 摘要 |
Cellular sensitivity to DNA damaging agents and progression through cell cycle is modulated through manipulation of T cell protein tyrosine phosphatase (TC-PTP) activity. Phenotypic characterization of cells lacking TC-PTP demonstrates a defective progression through the cell cycle, and sensitivity to DNA damaging agents. Screening assays are provided for selecting agents that affect the activity of TC-PTP, including assays relating to the interaction of TC-PTP with its substrate, p62dok.
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| 申请公布号 |
US6534056(B1) |
申请公布日期 |
2003.03.18 |
| 申请号 |
US19990466992 |
申请日期 |
1999.12.10 |
| 申请人 |
MCGILL UNIVERSITY |
发明人 |
TROMBLAY MICHEL L.;DE JESUS IBARRA SANCHEZ MARIA;SIMONCIC PAUL DANIEL |
| 分类号 |
G01N33/50;A61K31/711;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/47;C07K14/705;C12N5/06;C12N9/16;C12N15/09;C12Q1/42;G01N33/15;G01N33/566;G01N33/573;(IPC1-7):A61K51/00;A61M36/14;G01N33/53 |
主分类号 |
G01N33/50 |
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