发明名称 QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY
摘要 Compounds of formula I, (see fig. I) wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine ato ms; R2 represents an aryl group or a heteroaryl group, optionally substituted by C1-4 alkyl or SO2NH2; R3 represents a 4-, 5-, 6-. or 7-membered heterocyclic ring containing at le ast one heteroatom selected from N. O and S, the ring being optionally fused to a be nzene ring or a 5- or 6-membered heterocyclic ring containing at least one heteroatom select ed from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N: and L is absent, or represents a cyclic group of formula Ia. (see fig.Ia) or represents a chain of formula Ib, (see fig.Ib) ; and pharmaceutically acceptable salts thereof. are useful in the treatment o f a variety of disorders including benign prostatic hyperplasia.
申请公布号 CA2236239(C) 申请公布日期 2003.03.18
申请号 CA19982236239 申请日期 1998.04.29
申请人 PFIZER INC. 发明人 FOX, DAVID NATHAN ABRAHAM;COLLIS, ALAN JOHN
分类号 C07D239/94;A61K31/47;A61K31/4706;A61K31/505;A61K31/517;A61K31/535;A61K31/5355;A61K31/55;A61K31/551;A61P13/02;A61P13/08;A61P15/00;C07C255/61;C07D215/42;C07D239/95;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D405/12;C07D405/14;C07D471/04;(IPC1-7):C07D403/04;C07D243/08;A61K31/54 主分类号 C07D239/94
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