(2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors

摘要

Compounds of formula (i) and of formula (ii)wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.