Method for administering camptothecins via injection of pharmaceutical composition comprising coated particles of a camptothecin

摘要

A method for administering a camptothecin to a patient comprising: injecting into a patient a pharmaceutical composition comprising an aqueous suspension of solid particles suitable for intravenous delivery, the solid particles comprising a camptothecin, and a 0.3 nm to 3.0 mum thick layer of a membrane-forming amphipathic lipid wherein the solid particles have mean diameters between about 0.05 mum and 10 mum. The method is particularly well suited for delivering camptothecins, particularly 9-nitro-camptothecin intravenously.