发明名称 |
Inhibitors of prenyl-protein transferase |
摘要 |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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申请公布号 |
US6534506(B2) |
申请公布日期 |
2003.03.18 |
申请号 |
US20010828259 |
申请日期 |
2001.04.06 |
申请人 |
MERCK & CO., INC. |
发明人 |
NGUYEN DIEM N.;STUMP CRAIG A.;WILLIAMS THERESA M. |
分类号 |
A61P35/00;C07D498/22;C07D513/22;(IPC1-7):C07D498/22;C07D487/22;A61K31/529 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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