| 发明名称 |
Synthesis and use of amino acid fluorides as peptide coupling reagents |
| 摘要 |
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula:or the acid fluoride salts thereof whereinBLK is an N-amino protecting group;AA is an amino acid residue; andX is absent or a protecting group.The amino acid fluoride is useful as a coupling agent in peptide synthesis.
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| 申请公布号 |
US6534627(B1) |
申请公布日期 |
2003.03.18 |
| 申请号 |
US19990255503 |
申请日期 |
1999.02.23 |
| 申请人 |
RESEARCH CORPORATION TECNOLOGIES, INC. |
发明人 |
CARPINO LOUIS A.;EL-FAHAM AYMAN AHMED |
| 分类号 |
C07C237/22;C07C255/14;C07C271/10;C07C271/34;C07C275/40;C07C275/70;C07C317/04;C07C317/10;C07C317/14;C07C317/18;C07C321/14;C07C321/20;C07C323/14;C07D207/16;C07D209/20;C07D233/64;C07D233/68;C07D295/215;C07D317/18;C07K1/06;C07K1/08;C07K1/10;C07K1/113;(IPC1-7):C07K1/00 |
主分类号 |
C07C237/22 |
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