CYKLISCHE PEPTIDE, DIE AN DEN UROKINASE-TYPE PLASMINOGEN AKTIVATOR REZEPTOR BINDEN

摘要

Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the Calpha carbon of the first amino acid and the Calpha carbon of eleventh amino acid is between about 4 and 12 Ångstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.