| 摘要 |
<p>Cyclopenta[g]quinazolines of the formula (I):- wherein: A is a group OR or NR0R1 wherein R?0 and R1¿ are each independently hydrogen C¿l-4? alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or Cl-4 cyanoalkyl, or R?0 and R1¿ together with the intermediate N form a five- or six-membered heterocyclic ring; p is an integer in the range 1 to 4; R2 is hydrogen, C¿1-4? alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or Cl-4 cyanoalkyl; Ar?l¿ is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C¿l-4? alkyl and Cl-4 alkoxy; and R?3¿ is a group of one of the following formulae: -A?1-Ar2-A2-Y1 -A5¿-CON(R)CH(Y?4)Y5 -A8-X-Ar4¿ and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer.</p> |
