CHARACTERIZATION OF A FtsZ BINDING SITE AND USES THEREOF

摘要

The present invention relates to the ZipA-binding site of FtsZ, as determined using genetic and mutagenesis techniques. In particular, the present invention provides a ZipA-binding site of FtsZ, and a molecule having a ZipA-binding site. Also disclosed are mutant FtsZ proteins. The present invention is further directed to a method for identifying an agent which interacts with FtsZ, as well as an agent that interacts with FtsZ at a binding site. Finally, the present invention discloses a method for identifying an agent that interacts with a molecule having a ZipA-binding site, as well as an agent that interacts with a molecule having a ZipA-binding site.