DITHIAZOLE COMPOUNDS, MATRIX METALLOPROTEASE INHIBITORS AND EXTERNAL PREPARATIONS FOR THE SKIN

摘要

Dithiazole compounds of the general formula (I) or salts thereof: (I) [wherein R1 is hydrogen, alkyl, or the like; R2 is hydrogen, hydroxyl, alky, aryl, arylalkoxy, arylalkyl, or the like; and R3 is a group represented by the general formula (II), (III) or (IV): (II) (III) (IV) The compounds exhibit excellent inhibitory activity against matrix metalloproteases (MMPs) and are useful for pharmaceutical compositions, cosmetic compositions, or external preparations for the skin.