发明名称 |
ALGORITHM FOR ESTIMATING THE OUTCOME OF INFLAMMATION FOLLOWING INJURY OR INFECTION |
摘要 |
A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a "damage function" incident to bacterial infection or other serious inflammation. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL6), Interleukin 10 (IL10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt, which measures and interpolates differential data for a plurality of factors. In mammals, an IL6/NO ratio < 8 at 12 hours post infection is highly predictive (60%) of mortality; also in mammals, an IL6/NO ratio < 4 at 24 hours post infection is highly predictive (52%) of mortality; and an IL6/IL10 ratio in mammals of < 7.5 at 24 hours post infection is highly predictive (68%) of mortality.
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申请公布号 |
WO03021257(A1) |
申请公布日期 |
2003.03.13 |
申请号 |
WO2002US27582 |
申请日期 |
2002.08.30 |
申请人 |
THE UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION OF PENNSYLVANIA;CHOW, CARSON, C.;VODOVOTZ, YORAM;CLERMONT, GILLES |
发明人 |
CHOW, CARSON, C.;VODOVOTZ, YORAM;CLERMONT, GILLES |
分类号 |
C12Q1/68;G01N33/48;G01N33/50;G01N33/554;G01N33/569;G01N33/68;G01N33/84;G06F19/00;(IPC1-7):G01N33/48 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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