摘要 |
The invention provides isolated nucleic acids molecules, designated alpha2delta-4 nucleic acid molecules, which encode novel alpha-2/delta-subunits of the voltage-gated Ca2+ channel superfamily. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing alpha2delta-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an alpha2delta-4 gene has been introduced or disrupted. The invention still further provides isolated alpha2delta-4 polypeptides, fusion polypeptides, antigenic peptides and anti-alpha2delta-4 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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