| 摘要 |
<p>Nucleic acids comprising the neuregulin 1 gene (NRG 1) and encoding NRG 1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG 1 polypeptides; NRG 1 polypeptides; antibodies that bind to NRG 1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity ofNRG 1 polypeptide or which identify NRG 1 binding agents, and the agents or binding agents identified by the assays; NRG 1 therapeutic agents, including i the NRG 1 nucleic acids, NRG 1 polypeptides, or agents that alter the activity of an NRG 1 polypeptides; pharmaceutical compositions comprising the NRG 1 therapeutic agents; as well as methods of therapy of schizophrenia. Novel haplotypes with a common core haplotype in affected individuals are described, as well as their use in methods for screening for susceptibility to schizophrenia. Also described are hypomorphic mice for use in identifying phenotypes associated with schizophrenia, as well as for use in assessing agents of interest for neuroleptic activity and for potential therapeutic use for treatment of schizophrenia.</p> |
