发明名称 |
CYSTEINE PROTEASE INHIBITORS WITH 2-CYANO-4-AMINO-PYRIMIDINE STRUCTURE AND CATHEPSIN K INHIBITORY ACTIVITY FOR THE TREATMENT OF INFLAMMATIONS AND OTHER DISEASES |
摘要 |
The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors. |
申请公布号 |
WO03020278(A1) |
申请公布日期 |
2003.03.13 |
申请号 |
WO2002EP09661 |
申请日期 |
2002.08.29 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;ALTMAN, EVA;HAYAKAWA, KENJI;IWASAKI, GENJI |
发明人 |
ALTMAN, EVA;HAYAKAWA, KENJI;IWASAKI, GENJI |
分类号 |
A61K31/505;A61P1/02;A61P9/10;A61P11/00;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P21/04;A61P29/00;A61P33/00;A61P33/06;A61P33/12;A61P35/00;A61P37/02;A61P43/00;C07D239/42;C07D401/12;C07D403/12;(IPC1-7):A61K31/506 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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