| 发明名称 |
MODIFIED FACTOR IX |
| 摘要 |
The invention in particular relates to the modification of human factor IX to result in factor IX proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates, furthermore, to T-cell epitope sequences deriving from human factor IX, which are immunogenic. |
| 申请公布号 |
WO03020764(A2) |
申请公布日期 |
2003.03.13 |
| 申请号 |
WO2002EP09717 |
申请日期 |
2002.08.30 |
| 申请人 |
MERCK PATENT GMBH;CARR, FRANCIS, J.;CARTER, GRAHAM |
发明人 |
CARR, FRANCIS, J.;CARTER, GRAHAM |
| 分类号 |
C12N15/09;A61K38/00;A61P7/04;A61P43/00;C07K7/06;C07K7/08;C07K14/745;C12N9/64;C12N15/57;C12P21/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
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