A method of treating a substrate, which method comprises providing an electrolyte in contact with the substrate and an array of electrodes adjacent the surface and in contact with the electrolyte, and altering the potential of at least one electrode so as to generate an active redox product which modifies the substrate adjacent the at least one electrode, characterised in that the electrolyte is chosen such that the active redox product is quenchable by a second redox product. The method is particularly suitable for the step-wise chemical synthesis of oligomers such as oligonucleotides bound to a surface.
申请公布号
WO03020415(A2)
申请公布日期
2003.03.13
申请号
WO2002GB03992
申请日期
2002.09.02
申请人
ISIS INNOVATION LIMITED;SOUTHERN, EDWIN, MELLOR;EGELAND, RYAN, D.