RECOMBINANT VECTOR EXPRESSING A BETA2-ADRENERGIC RECEPTOR AND USE IN TREATING AIRWAY AND VASCULAR DISEASES

摘要

A method of treating a human having airway or vascular disease comprises administering to at least one cell type selected from airway epithelial cells, airway smooth muscle cells, blood vessel endothelial cells, and blood vessel smooth muscle cells, a first composition comprising a vector comprising a DNA sequence encoding a beta 2AR ( beta 2-adrenergic receptor) or a mutant thereof, operably linked to a promoter that is functional in at least one of said cells said subject, and optionally a second composition comprising at least one beta 2-adrenergic agonist. Pharmaceutical compositions comprising the vector comprising a DNA sequence encoding a beta 2AR or a mutant thereof, operably linked to a promoter that is functional in at least one of the cells of the subject and kits containing these compositions as well as.. An in vitro method of expressing the beta 2AR gene in mammalian cells and a method of evaluating the effect of pharmacological compounds on the expression of the beta 2AR gene is disclosed.