ANTI-CANCER CYCLOPENTA[G]QUINAZOLINE COMPOUNDS

摘要

Cyclopenta[g]quinazolines of the formula (I):- wherein: A is a group OR or NR<0>R<1> wherein R<0> and R<1> are each independently hydrogen Cl-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or Cl-4 cyanoalkyl, or R<0> and R<1> together with the intermediate N form a five- or six-membered heterocyclic ring; p is an integer in the range 1 to 4; R<2> is hydrogen, C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 halogenoalkyl or Cl-4 cyanoalkyl; Ar<l> is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, Cl-4 alkyl and Cl-4 alkoxy; and R<3> is a group of one of the following formulae: -A<1>-Ar<2>-A<2>-Y<1> -A<5>-CON(R)CH(Y<4>)Y<5> -A<8>-X-Ar<4> and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer.