THERAPEUTIC PROCESS FOR P. AERUGINOSA INFECTIONS USING MACROLIDE ANTIBIOTICS

摘要

Macrolides, in particular azalides such as azithromycin, are suited for the treatment of nosocomial infections caused by P. aeruginosa. The mechanism of action is the inhibition of the quorum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxododecanoyl]-L-homoserine lactone and N-butyrylhomoserine lactone. This allows for treatments of P. aeruginosa infections at non-inhibiting concentrations of the macrolide.