IMIDIAZOLE DERIVATIVES AND THEIR USE AS AGONISTS SELECTIVE AT ALPHA 2B OR 2B/2C ADRENERGIC RECEPTORS

摘要

A compound having a structure selected from the group consisting of: in which each x is independently (1) or (2); Y is selected from the group consisting of O;S;N;-(C(R7)z)s-where each R7 IS independently as previously defined fir R1, each z is independently 1-2, and s is 1-3;CH=; -CH=CH ;or Y1CH2_where Y1 is O, N, or S; and the dotted lines are optional double bonds, with the pviso that if the ring including Y is a cyclohexane ring or a heterocyclic 5 member ring said ring is not fully unsaturated, and that if Y is O,N or S, the ring including Y contains at least one said double bond, said compound further having selective agonist activity at the alpha 2B or alpha 2B/ alpha 2C adrenergic receptor subtype(s) over the alpha 2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof.