METHODS TO INCREASE THE PRODUCTIVITY OF METEROLOGOUS GENE EXPRESSION

摘要

The present invention provides a method of increasing heterologous protein expression/production in a cell by controlling proteolysis in the post ER compartment of the cell. Proteolysis can be controlled by limiting/preventing export of proteins from the ER to the post ER compartment of the cell and/or by re-directing proteins from the vacuolar sorting route back to the ER or on towards the cell surface.