CYCLIC AMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

Cyclic amine compounds of formula R1-R2CH-R3 (I) are new. R1 = phenyl optionally substituted by 1-4C alkyl, halo, fluoro-substituted 1-4C alkyl, 1-4C alkoxy, fluoro-substituted 1-4C alkoxy, cyano or nitro; R2 = 1-8C aliphatic acyl optionally substituted by halo, OH, 1-4C alkoxy or cyano; benzoyl optionally substituted by 1-4C alkyl, halo or 1-4C alkoxy; or (1-4C alkoxy)carbonyl; R3 = optionally condensed 3-7 membered cyclic saturated amino group substituted by optionally protected mercapto or 1-4C alkyl optionally substituted by optionally protected mercapto; CR4R5 (mercapto-protecting groups are 1-20C alkanoyl, 3-20C alkenoyl, benzoyl optionally substituted by 1-4C alkyl, halogen or 1-4C alkoxy); or (1-4C alkoxy)carbonyl; and R4, R5 = H, 1-4C alkyl, carboxy, (1-4C alkoxy) carbonyl, carbamoyl or mono- or di-(1-4C alkyl)carbamoyl.