Flow cell system for solubility testing

摘要

Flow cell system for high throughput solubility testing of compounds. The system includes a flow cell to channel a fluid sheath which itself channels a continuous or intermittent sample liquid stream containing a compound for testing. Where the concentration of compound in the sample exceeds the solubility limit, particles of the test compound precipitate. These particles scatter the light from an interrogating light beam directed at the sample liquid stream. Individual flashes of scattered light are detected as electronic pulse signals from the detector and their intensity analyzed according to intensity and number of events. System software analyzes the stored pulse signal data in real-time to determine whether there is a significant increase in scattering over the highly variable background scattering. The software then outputs a signal to effectuate selection of a subsequent sample. <IMAGE> <IMAGE> <IMAGE>