DIALYSATE PERITONEAL DIALYSIS AND ITS PREPARATION METHOD

摘要

Although glucose has been mainly employed in peritoneal dialysis for treatin g renal failure, there arises a problem that protein undergoes crosslinking du e to the oxidation and denaturation of glucose and thus hardens peritoneal tissue, thereby making it impossible to continue the peritoneal dialysis. To overcome this problem, peritoneal dialysates containing a protein crosslinki ng inhibitor or an agent dissociating protein crosslinkage once formed are provided. As the protein crosslinking inhibitor or the agent dissociating protein crosslinkage once formed, it is effective to use reducing agents or antioxidants. These peritoneal dialysates are prepared by sterilizing peritoneal dialysates under elevated pressure at high temperature prior to t he addition of the inhibitor(s), then individually sterilizing the inhibitor(s) and adding the same.