| 摘要 |
PROBLEM TO BE SOLVED: To provide a therapeutic agent having markedly and selectively Rho kinase-inhibitory activity, free from any problematic toxicity, having favorable oral absorbability and pharmacokinetics (medicinal absorption, distribution, metabolism and excretion) and good physical properties (e.g. stability) in terms of compound, and useful for various diseases involving Rho kinase. SOLUTION: The objective Rho kinase inhibitor comprises an amide compound of the general formula (I) [where, Ra is a (substituted) nitrogen-containing heterocyclic ring; Rb is H or the like; and Rc is an aryl bearing 1-5 substituent(s) being the same or different, or the like]. An isomer thereof or a pharmaceutically acceptable salt thereof is an option of the inhibitor.
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