| 发明名称 |
Hydroxamic acid derivatives, process of their preparation and use as well as pharmaceutical compositions based thereon |
| 摘要 |
<p>Deriv ty hydroxamov²ch kyselin obecn ho vzorce I jako takov a pro pou it jako terapeuticky · inn l tky a pro l en chorob. Zp sob p° pravy t chto deriv t oxidac slou eniny obecn ho vzorce II. Pou it t chto deriv t pro v²robu l iva pro l bu chorobn ho stavu, kter² je zm rn n oÜet°en m inhibitorem matricov metaloprote zy, zejm na kde chorobn²m stavem je rheumatoidn artritida, osteoartritida, osteopor za, periodont ln choroba, aberantn angiogeneze, roztrouÜen skler za, tumorov metast zy nebo korne ln ulcerace nebo kde chorobn² stav je zp soben faktorem tumorov nekr zy, zejm na kde chorobn²m stavem je z n t, hemorrhagie, reakce transplant t versus hostitel nebo autoimunitn choroba; a pro v²robu l iva pro l en chronick obstruktivn pulmon rn choroby. Farmaceutick kompozice na b zi t chto deriv t ./</p> |
| 申请公布号 |
CZ291478(B6) |
申请公布日期 |
2003.03.12 |
| 申请号 |
CZ19960003740 |
申请日期 |
1996.12.18 |
| 申请人 |
F. HOFFMANN - LA ROCHE AG;AGOURON PHARMACEUTICALS, INC. |
发明人 |
BENDER STEVEN LEE;BROKA CHRIS ALLEN;CAMPBELL JEFFREY ALLEN;CASTELHANO ARLINDO LUCAS;HENDRICKS ROBERT THAN;SARMA KESHAB;FISHER LAWRENCE EMERSON |
| 分类号 |
C07D333/34;A61K31/00;A61K31/10;A61K31/165;A61K31/18;A61K31/185;A61K31/34;A61K31/341;A61K31/35;A61K31/351;A61K31/38;A61K31/381;A61K31/382;A61K31/44;A61K31/4402;A61K31/4427;A61K31/4433;A61K31/445;A61K31/4465;A61P1/00;A61P1/02;A61P3/00;A61P5/00;A61P19/00;A61P19/10;A61P27/00;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07C259/06;C07C315/02;C07C317/44;C07C323/51;C07D211/54;C07D213/64;C07D213/643;C07D307/14;C07D309/08;C07D335/02;C07D401/04;C07D401/06;C07D405/12;C07D407/12;C07D409/12;C07D413/12;(IPC1-7):C07D309/08 |
主分类号 |
C07D333/34 |
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