发明名称 |
NUCLEAR FACTOR KB INDUCING FACTOR |
摘要 |
The present invention is directed to nuclear factor kB (NFkB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NKkB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFkB induction in a patient, methods and compositions for lowering NFkB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treament and/or prevention of an NFkB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided. |
申请公布号 |
EP1290023(A2) |
申请公布日期 |
2003.03.12 |
申请号 |
EP20010920925 |
申请日期 |
2001.04.02 |
申请人 |
AVENTIS PHARMACEUTICALS PRODUCTS INC. |
发明人 |
KAPLOW, JUNE;HAWS, THOMAS;ROSIER, MARIE;DENEFLE, PATRICE |
分类号 |
C07K14/47;C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P9/10;A61P29/00;A61P37/02;A61P43/00;C12Q1/68;(IPC1-7):C07K14/475 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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