发明名称 (2-AZABICYCLO[2.2.1]HEPT-7-YL)METHANOL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
摘要 The invention relates to substances of general formula (I), wherein X is selected from the following group: NH, NR4, O and S, R1 is selected from the following group: hydrogen, linear and branched, substituted and unsubstitute d C1-C10-alkyl groups, substituted and unsubstituted C5-C10-aryl groups, substituted and unsubstituted C4-C10-heteroaryl groups, acyl groups, thioacy l groups, carbonyl carboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, R2, R3, independently of each other, are chosen from the following group: C1-C10-alkyl groups, C5-C12-aryl groups and C4-C12- heteroaryl groups, these groups being unsubstituted or having one or more substitutents which are chosen independently of each other from the followin g group: halogens, alkoxy groups, aryloxy groups, nitro groups, C1-C5- alkoxycarbonyl groups, alkyl or acyl groups and cyano groups, optionally substituted with fluorine, and R4 is selected from the following group: hydrogen, linear and branched, substituted and unsubstituted C1-C10-alkyl groups, substituted and unsubstituted C5-C10-aryl groups, substituted and unsubstituted C4-C10-heteroaryl groups, acyl groups, thioacyl groups, carbon yl carboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups; or a physiologically compatible salt thereof.
申请公布号 CA2421936(A1) 申请公布日期 2003.03.11
申请号 CA20012421936 申请日期 2001.09.11
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG 发明人 SCHIEMANN, KAI;LEIBROCK, JOACHIM
分类号 A61K31/403;A61P25/00;A61P25/16;A61P25/18;A61P25/28;A61P25/30;A61P39/02;A61P43/00;C07D209/52;C07D401/12;(IPC1-7):C07D209/52 主分类号 A61K31/403
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