CRYSTAL STRUCTURES OF P SELECTIN,EP0105895 SELECTIN COMPLEXES, AND USES THEREOF.

摘要

EP0105854nt invention relates to the crystal and three dimensional structures of the lectin and EGF like (LE) domains of P selectin, the crystal and three dimensional structures of P selectin LE and E selectin LE each complexed with SLeX, as well as the crystal and three dimensional structure of P selectin LE complexed with a functional PSGL 1 peptide modified by both tyrosine sulfation and SLeX. The present invention also provides methods for identifying agents which activate or inhibitor each of the foregoing structures. In addition, the present invention provides agents identified by such methods.