发明名称 |
GPI-ANCHORED CYTOKINES |
摘要 |
The present invention relates to immunogenic compositions for stimulating T cell proliferation and methods for enhancing therapeutic effectiveness of so me traditional anti-cancer treatments. Specifically, local delivery of cytokine s that target the plasma membrane of a cancerous cell exhibit more potent anti - tumor effects than systemic delivery of cytokines in soluble form. Figure 2 shows pulmonary metastasis images of untreated tumor cells with tumor cells treated with soluble IL-2 and tumor cells treated with GPI anchored IL-2.</S DOAB>
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申请公布号 |
CA2458236(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
CA20022458236 |
申请日期 |
2002.08.27 |
申请人 |
GREENVILLE HOSPITAL SYSTEM |
发明人 |
WEI, YANZHANG;WAGNER, THOMAS E. |
分类号 |
A61K38/20;A61K39/00;A61K48/00;C07K14/55;C12N15/12;(IPC1-7):A61K31/70;C12N5/00;C07H21/04;C12N5/06;C12N15/63 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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