PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER

摘要

Disclosed herein are modified proaerolysin (PA) peptide. In some examples, t he proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replace s the native PA binding domain. In other examples, The proteins include a furi n cleavage site and a prostate tissue-specific binding domain which functional ly replaces the native PA binding domain. Methods of using such peptides to tre at prostate cancer are also disclosed.