发明名称 |
Pharmaceutical composition having reduced tendency for drug crystallization |
摘要 |
An orally deliverable pharmaceutical composition is provided comprising a drug of low water solubility, a solvent liquid that comprises at least one pharmaceutically acceptable solvent, and a turbidity-decreasing polymer, wherein (a) a substantial portion, for example at least about 15% by weight, of the drug is in dissolved or solubilized form in the solvent liquid, and (b) the polymer is present in an amount sufficient to substantially inhibit crystallization and/or precipitation of the drug in simulated gastric fluid.
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申请公布号 |
US2003045563(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
US20020047222 |
申请日期 |
2002.01.15 |
申请人 |
GAO PING;HAGEMAN MICHAEL J.;MOROZOWICH WALTER;DALGA ROBERT J.;STEFANSKI KEVIN J.;HUANG TIEHUA;KARIM AZIZ;HASSAN FRED;FORBES JAMES C. |
发明人 |
GAO PING;HAGEMAN MICHAEL J.;MOROZOWICH WALTER;DALGA ROBERT J.;STEFANSKI KEVIN J.;HUANG TIEHUA;KARIM AZIZ;HASSAN FRED;FORBES JAMES C. |
分类号 |
A61K9/08;A61K9/107;A61K9/48;A61K31/00;A61K31/122;A61K31/337;A61K31/352;A61K31/365;A61K31/415;A61K31/42;A61K31/444;A61K31/50;A61K31/52;A61K31/522;A61K45/00;A61K47/30;A61K47/32;A61K47/34;A61K47/38;A61P25/04;A61P25/06;A61P29/00;A61P43/00;(IPC1-7):A61K31/415;A61K31/44;A61K31/443;A61K31/18;A61K31/10 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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