MOLECULAR INTERACTION SITES OF HEPATITIS C VIRUS RNA AND METHODS OF MODULATING THE SAME

摘要

Polynucleotides comprising molecular interaction sites of hepatitis C virus RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatoriallibraries of compounds that bind thereto are also provided. Method of modulating the activity of hepatitis C virus RNA by contacting hepatitis C virus RNA or cells containing the same with a compound identified by such virtual or actual screening are also provided.