发明名称 |
3-HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE AND DIAGNOSIS AND PROGNOSTICATION OF DEMENTIA |
摘要 |
The invention relates to methods and commercial packages for the diagnosis and/or prognostication of a dementia. The methods are based upon the assessment of a feature or features relating to 3-hydroxymethylglutaryl coenzyme A reductase (HMGR) gene, a polymorphism associated with the gene, t he nature of mRNA transcripts produced, and/or HMGR protein activity. Applicant s have determined that a decrease in HMGR activity correlates with Alzheimer disease. Applicants have further determined that the presence of a polymorphism in the HMGR gene correlates with Alzheimer disease. Applicants have identified two abnormal HMGR mRNA transcripts and have shown that their presence correlates , with Alzheimer disease. |
申请公布号 |
CA2496398(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
CA20022496398 |
申请日期 |
2002.08.29 |
申请人 |
MCGILL UNIVERSITY |
发明人 |
AUMONT, NICOLE;POIRIER, JUDES;DEA, DORIS;THEROUX-LAMARRE, LOUISE |
分类号 |
C12Q1/26;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/26 |
代理机构 |
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代理人 |
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地址 |
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