发明名称 |
CONTROLLED RELEASE OF ANTI-ARRHYTHMIC AGENTS FROM A BIODEGRADABLE POLYETHYLENE OXIDE HYDROGEL FOR LOCAL APPLICATION TO THE HEART |
摘要 |
Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti-arrhythmia drugs are incorporated into hydrogels that biodegrade and adhere to the tissues to which the anti-arrhythmic drugs are to be delivered. The hydrogels may be formed in vitro or in vivo. In a preferred embodiment, the drugs are effective to lengthen atrial effective refractory period. A particularly preferred drug is amiodarone. |
申请公布号 |
WO02051383(A3) |
申请公布日期 |
2003.03.06 |
申请号 |
WO2001US49617 |
申请日期 |
2001.12.27 |
申请人 |
GENZYME CORPORATION;FOCAL, INC. |
发明人 |
PHILBROOK, MICHAEL, C.;BURNS, JAMES, W.;SKINNER, KEVIN, C.;MILLER, ROBERT, J. |
分类号 |
A61K47/32;A61K9/00;A61K9/06;A61K31/343;A61K47/34;A61K47/36;A61K47/38;A61L24/00;A61P9/06 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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