| 摘要 |
The invention relates to ribozymes modified to improve their stability, methods for producing such enzymes and the use of the modified enzymes in methods such as therapeutic treatment. In particular, a typical ribozyme according to the invention includes a modified ribozyme, wherein three or more pyrimidine nucleotides in said ribozyme are modified at the 2'-position, wherein said pyrimidine nucleotides are modified to 2'-amino pyrimidine nucleotides and said ribozyme exhibits improved stability to RNAse degradation and exhibits 85% or more catalytic activity of the unmodified ribozyme.
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