INHIBITION OF PROTEIN-PHOSPHATASES FOR THE TREATMENT OF HEART FAILURE

摘要

There is provided a method for treating an individual with cardiovascular disease, including the step of administering a therapeutically effective amount of protein phosphatase inhibitor and analogues thereof, to the individual after the onset of cardiac ischemia. Also provided is a method of treating an individual with cardiovascular disease by selectively inhibiting protein phosphatase activity in the heart. A composition for the treatment of heart failure, the composition including an inhibitor of PP1 and a pharmaceutically acceptable carrier is also provided. There is provided a sequence encoding inhibitor-2.